Carbon Dioxide → 2,2,2-Trifluoroethyl trifluoromethanesulfonate

Temperature

0 °C

A solution of trifluoromethanesulfonyl chloride (800 uL, 7.5 mmole) in CH2Cl2 (6 mL) was cooled under argon to -60° C. (IPA:dry ice bath). 2,2,2-Trifluoroethanol was added (456 uL, 6 mmol) and triethylamine (1.04 uL, 7.5 mmol) was added dropwise. The reaction was stirred for 1.5 hours then warmed to 0° C. for 1 hour. Anhydrous ether (20 mL) was added and the mixture was stirred at 0° C. for 30 minutes. The solids were filtered off and the solvent was removed under reduced pressure with the flask maintained at 0° C. This afforded the 2,2,2-trifluoroethyltriflate as a yellow oil which was used immediately.

1. additionwas added dropwise
2. stirringthe mixture was stirred at 0° C. for 30 minutes
3. filtrationThe solids were filtered off
4. customthe solvent was removed under reduced pressure with the flask
5. temperaturemaintained at 0° C

ORD record

ord-c1eb50330c204669ac80b93517bb8dec

Source dataset

uspto-grants-1998_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05726172