Triethylamine → 2-Propenoic acid, 3-phenyl-

HRID 1743280

Reaction equation

HRID 1743280 reaction equation
Br[C@H:2]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].C(N(CC)CC)C>C(OCC)(=O)C>[C:3]([OH:5])(=[O:4])[CH:2]=[CH:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 11746403(R)-2-Bromo-3-phenylpropionic acid

Product 1

HCID 87842-Propenoic acid, 3-phenyl-

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5 g of crude (2R)-2-bromo-3-phenylpropionic acid (HPLC: 92.5%) were dissolved in 20 ml of ethyl acetate and treated at room temperature with 2.7 ml of triethylamine. After a stirring time of about 150 minutes, no precipitation of the product was to be observed. An HPLC analysis of the solution showed that the (2R)-2-bromo-3-phenyl-propionic acid had reacted completely to give cinnamic acid.

Workup

  1. customAfter a stirring time of about 150 minutes, no precipitation of the product
  2. customhad reacted completely

Sources & evidence

ORD record
ord-fa8f039f982e47f59386fc1d90ea5567
Source dataset
uspto-grants-2006_03
Patent number
US07009047B2

Linked notes

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