Hydrochloric Acid → 2,6-Dimethoxy-4-(2-thiazolidinyl)phenol
Reaction equation
[CH:1](=O)[C:2]1[CH:12]=[C:9]([O:10][CH3:11])[C:7]([OH:8])=[C:4]([O:5][CH3:6])[CH:3]=1.[NH2:14][CH2:15][CH2:16][SH:17].Cl.C([O-])(=O)C.[Na+]>O.C(O)C>[CH3:11][O:10][C:9]1[CH:12]=[C:2]([CH:1]2[NH:14][CH2:15][CH2:16][S:17]2)[CH:3]=[C:4]([O:5][CH3:6])[C:7]=1[OH:8]Participants
7
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Procedure
In a solvent including an ethyl alcohol (2 mL) and water (2 mL), a mixture including syringaldehyde (100 mg, 0.55 mmol), cysteamine.HCl (93.2 mg, 0.82 mmol), and sodium acetate (72 mg, 0.88 mmol) was stirred at room temperature for 4 hours. The produced precipitate was filtered and washed with water and methylene chloride to obtain a solid target product Compound 80.
Workup
- filtrationThe produced precipitate was filtered
- washwashed with water and methylene chloride
Sources & evidence
- ORD record
- ord-a65ed457c7144e9aacce7881bf17588a
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09155690B2
Reaction notes
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