Phenacyl bromide → HCID 178444626, compound
Reaction equation
C#CCCCCC=O.c1ccc(C(=O)CBr)cc1>C1COCCN1.COc1ccc(-c2cc(-c3ccc(OC)cc3)[o+]c(-c3ccc(OC)cc3)c2)cc1.[B-](F)(F)(F)F.CN(C)C=O.Cc1cccc(C)n1>C#CCCC[C@@H](C=O)CC(=O)c1ccccc1.C#CCCC[C@H](C=O)CC(=O)c1ccccc1Participants
8
Reactant 3
Product 2
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 22 °C
Workup
- aliquot4 uL mixture of each reacted solution was collected and diluted with 36 uL ACN
- addition4 uL mixture of each reacted solution was collected and diluted with 36 uL ACN
- additionchiral resolving regent (150 mM in DCM, 40 uL)
- additionCuI with DIPEA (400 mM in ACN) 40 uL
- additioninternal standard 1-phenylprop-2-yn-1-ol (4) (25 mM in ACN) 40 uL
- stirringNo procedure recorded
- aliquotAfter the reaction, 10 uL of supernatant for each reaction was transferred to another 96-well plate
- additionAfter the reaction, 10 uL of supernatant for each reaction was transferred to another 96-well plate and diluted with 190 uL ACN before the IM-MS analysis
Sources & evidence
- ORD record
- ord-de61914fecf243a88cfe0984e53786ad
- Source dataset
- Dataset from `Ultra-high-throughput mapping of the chemical space of asymmetric catalysis enables accelerated reaction discovery`
Reaction notes
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