Hydrochloric Acid → HCID 54710388, compound
Reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.CC1OCCC1.Cl.O1CCOCC1>CCOC(C)=O>[NH:5]1[C:6]2[C:11](=[N:10][CH:9]=[CH:8][CH:7]=2)[C:2](=[O:1])[CH2:3][CH2:4]1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of tert-butyl 4-oxo-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate (1 eq.) and 2-MeTHF (0.2 M) is added 4M HCl in dioxane (5 eq.). The reaction is monitored by TLC. The reaction is diluted with EtOAc and washed with saturated NaHCO3. The organic solution is dried over MgSO4 and concentrated in vacuo. The compound that may be thus obtained is purified by column chromatography to give the title compound.
Workup
- washwashed with saturated NaHCO3
- dry with materialThe organic solution is dried over MgSO4
- concentrationconcentrated in vacuo
- customThe compound that may be thus obtained
- customis purified by column chromatography
Sources & evidence
- ORD record
- ord-b987a6e58c364847b5da333618fcc3a9
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08952009B2
Reaction notes
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