Hydroxylamine → 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide

HRID 195825

Reaction equation

HRID 195825 reaction equation
[CH2:67]1[O:68][CH2:69][CH2:70][CH2:71]1.[NH2:1][OH:2].[NH2:36][C:37](=[O:38])[c:39]1[cH:40][cH:41][cH:42][cH:43][c:44]1[C:45]([NH2:46])=[O:47].[c:3]1(-[c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[cH:4][cH:5][c:6]([S:9](=[O:10])(=[O:11])[N:12]2[CH:13]([C:17](=[O:18])[NH:19][CH:20]([CH2:21][CH2:22][OH:23])[c:24]3[cH:25][cH:26][cH:27][cH:28][cH:29]3)[S:14][CH2:15][CH2:16]2)[cH:7][cH:8]1.[c:48]1([P:49]([c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)[c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[cH:62][cH:63][cH:64][cH:65][cH:66]1>>[c:3]1(-[c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[cH:4][cH:5][c:6]([S:9](=[O:10])(=[O:11])[N:12]2[CH:13]([C:17](=[O:18])[NH:19][CH:20]([CH2:21][CH2:22][N:46]3[C:37](=[O:38])[c:39]4[cH:40][cH:41][cH:42][cH:43][c:44]4[C:45]3=[O:47])[c:24]3[cH:25][cH:26][cH:27][cH:28][cH:29]3)[S:14][CH2:15][CH2:16]2)[cH:7][cH:8]1

Participants

6

Reactant 5

HCID 787HydroxylamineHCID 6956PhthalamideHCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 103110413-([1,1'-biphenyl]-4-ylsulfonyl)-N-(3-hydroxy-1-phenylpropyl)-1,3-thiazolidine-2-carboxamide

Product 1

HCID 686220633-([1,1'-biphenyl]-4-ylsulfonyl)-N-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide

Sources & evidence

ORD record
ord-0173e7040b954371aa3b1d22c7e8f4a8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

Loading…