2-Bromopropane → alpha-Isopropyl-3,5-dimethoxyphenylacetonitrile

HRID 1979532

Reaction equation

HRID 1979532 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C:12]#[N:13])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[CH:14](Br)([CH3:16])[CH3:15].[H-].[Na+]>CN(C=O)C>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([CH:11]([CH:14]([CH3:16])[CH3:15])[C:12]#[N:13])[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

Participants

5

Reactant 3

HCID 63582-BromopropaneHCID 24758Sodium hydrideHCID 1394453,5-Dimethoxyphenylacetonitrile

Product 1

HCID 14183624alpha-Isopropyl-3,5-dimethoxyphenylacetonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent3×

Procedure

This is prepared by reacting a solution of 2-(3,5-dimethoxyphenyl)-acetonitrile (4 g, 0.022 mol) in 10 cc of DMF with 2.86 g of isopropyl bromide in 5 cc of DMF, in the presence of a 50% suspension of 1.1 g of sodium hydride in 25 cc of DMF.

Workup

  1. customThis is prepared

Sources & evidence

ORD record
ord-d047fe9f29f94682b2e0ae160cb0a8d9
Source dataset
uspto-grants-1984_11
Patent number
US04481207

Linked notes

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