Triethylsilicon → tert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate
Reaction equation
CC[SiH](CC)CC.Clc1cc(Cl)c(O[CH:1]=[O:2])c(Cl)c1.[CH3:3][C:4]([O:7][C:8]([N:10]1[CH2:27][c:26]([c:13]2[CH2:12][CH2:11]1)[c:17]([O:18][CH2:19][c:20]3[cH:25][cH:24][cH:23][cH:22][cH:21]3)[cH:16][c:15](Br)[cH:14]2)=[O:9])([CH3:6])[CH3:5]>>[CH3:3][C:4]([O:7][C:8]([N:10]1[CH2:27][c:26]([c:13]2[CH2:12][CH2:11]1)[c:17]([O:18][CH2:19][c:20]3[cH:25][cH:24][cH:23][cH:22][cH:21]3)[cH:16][c:15]([CH:1]=[O:2])[cH:14]2)=[O:9])([CH3:6])[CH3:5]Participants
8
Reactant 3
Product 1
Reagents, catalysts & solvents 4
Conditions
- Temperature
- 90 °C
Sources & evidence
- ORD record
- ord-9a6a9fcf9a9243bd983154b5ce158361
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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