4-Methylidene-2,3-dihydroisoquinolin-1-one → 4-Methyl-3,4-dihydroisoquinolin-1(2H)-one

HRID 2008791

Reaction equation

HRID 2008791 reaction equation

[CH2:1]=[C:2]1[c:12]([c:7]2[C:5](=[O:6])[NH:4][CH2:3]1)[cH:11][cH:10][cH:9][cH:8]2>>[CH3:1][CH:2]1[c:12]([c:7]2[C:5](=[O:6])[NH:4][CH2:3]1)[cH:11][cH:10][cH:9][cH:8]2

Participants

7

Reactant 1

HCID 1299777774-Methylidene-2,3-dihydroisoquinolin-1-one

Product 1

HCID 140400954-Methyl-3,4-dihydroisoquinolin-1(2H)-one

Reagents, catalysts & solvents 5

HCID 10909155(1R,2R)-N1,N2-Bis(2-(diphenylphosphino)benzyl)cyclohexane-1,2-diamineCatalyst

HCID 178420230HCID 178420230, compoundCatalyst

HCID 111,2-DichloroethaneSolvent

HCID 7924Propylene CarbonateSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 20 °C

Sources & evidence

ORD record: ord-66bb5d3c43a44a4ba7af0fc8f533699a
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Linked notes

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