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1,4-Dimethyl-1H-1,2,3-triazole → {[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one

HRID 2015830
Notes
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Reaction equation

HRID 2015830 reaction equation
[CH3:1][c:2]1[n:30][c:21]([O:22][CH2:23][c:24]2[cH:29][cH:28][cH:27][cH:26][cH:25]2)[c:6]([CH2:7][N:8]3[C:19](=[O:20])[c:18]([c:11]4[CH2:10][CH2:9]3)[c:16]([Cl:17])[c:15](Br)[cH:14][c:12]4[Cl:13])[c:4]([CH3:5])[cH:3]1.[CH3:31][c:32]1[n:37][n:36][n:34]([CH3:35])[cH:33]1>>[CH3:1][c:2]1[n:30][c:21]([O:22][CH2:23][c:24]2[cH:29][cH:28][cH:27][cH:26][cH:25]2)[c:6]([CH2:7][N:8]3[C:19](=[O:20])[c:18]([c:11]4[CH2:10][CH2:9]3)[c:16]([Cl:17])[c:15]([c:33]5[n:34]([CH3:35])[n:36][n:37][c:32]5[CH3:31])[cH:14][c:12]4[Cl:13])[c:4]([CH3:5])[cH:3]1
ParticipantsConditionsSources & evidenceReaction notes

Participants

8

Reactant 2

HCID 152571421,4-Dimethyl-1H-1,2,3-triazoleHCID 867237282-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-7-bromo-5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one

Product 1

HCID 86723731{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one

Reagents, catalysts & solvents 5

HCID 583616Cesium pivalateReagent
HCID 167845
palladium(II) acetate
Catalyst
HCID 32553464,6-Bis(diphenylphosphino)-10H-phenoxazineCatalyst
HCID 31374DimethylacetamideSolvent
HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
90 °C

Sources & evidence

ORD record
ord-f9590be8e3af4afcaf25714608bd0886
Source dataset
39k HTE dataset from Pfizer
DOI
10.1038/s41557
Original link
View source

Reaction notes

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On this pageParticipantsConditionsSources & evidenceReaction notes