Iodoethane → HCID 54234050, compound

(S)-2-Amino-4-methyl-1-pentanethiol (6.66 g, 50 mmol) is added over 45 minutes to a well stirred slurry of 60% sodium hydride (2.0 g, 50 mmol) in THF (50 mL) at room temperature under N2. After all of the sodium hydride has reacted, a solution of ethyl iodide (4 mL, 50 mmol) in THF (50 mL) is added and the reaction stirred at 20°-25° C. for 18 hours. THF is removed under reduced pressure and the residue partitioned between diethylether and brine. The ether extract is dried (Na2SO4), filtered and concentrated under reduced pressure. Flash chromatograp

1. customTHF is removed under reduced pressure
2. customthe residue partitioned between diethylether and brine
3. extractionThe ether extract
4. dry with materialis dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure

ORD record

ord-ea3cc594a12c4829b6285a8e058a0629

Source dataset

uspto-grants-1991_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05019647