Hydrochloric Acid → 3,3-Bis(4-fluorophenyl)-1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)pyrrolidin-2-one

HRID 205554

Reaction equation

HRID 205554 reaction equation
[CH2:43]([N:44]=[C:45]=[N:46][CH2:47][CH2:48][CH2:49][N:50]([CH3:51])[CH3:52])[CH3:53].[CH3:57][N:58]([CH3:59])[c:60]1[cH:61][cH:62][n:63][cH:64][cH:65]1.[Cl:54][CH2:55][Cl:56].[ClH:42].[F:18][c:19]1[cH:20][cH:21][c:22]([C:25]2([c:35]3[cH:36][cH:37][c:38]([F:41])[cH:39][cH:40]3)[C:26](=[O:34])[N:27]([CH2:30][C:31](=[O:32])[OH:33])[CH2:28][CH2:29]2)[cH:23][cH:24]1.[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[cH:13][cH:14][cH:15]1)([F:16])[F:17]>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]2[CH2:8][CH2:9][N:10]([C:31]([CH2:30][N:27]3[C:26](=[O:34])[C:25]([c:22]4[cH:21][cH:20][c:19]([F:18])[cH:24][cH:23]4)([c:35]4[cH:36][cH:37][c:38]([F:41])[cH:39][cH:40]4)[CH2:29][CH2:28]3)=[O:32])[CH2:11][CH2:12]2)[cH:13][cH:14][cH:15]1)([F:16])[F:17]

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 142844-(Dimethylamino)pyridineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 20608551-(3-(Trifluoromethyl)benzyl)piperazineHCID 673571912-(3,3-Bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid

Product 1

HCID 574020393,3-Bis(4-fluorophenyl)-1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)pyrrolidin-2-one

Sources & evidence

ORD record
ord-84fb69c86f63475c9a86d6b51914e7bd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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