Isoflurane → Desflurane

HRID 2061939

Reaction equation

HRID 2061939 reaction equation
[CH:1]([F:10])([O:6][CH:7]([F:9])[F:8])[C:2]([F:5])([F:4])[F:3].F.C(Cl)(OC(F)F)C(F)(F)[F:14]>O=[Cr]O[Cr]=O>[CH:1]([F:10])([O:6][CH:7]([F:9])[F:8])[C:2]([F:5])([F:4])[F:3].[CH:1]([F:10])([O:6][CH:7]([F:9])[F:8])[C:2]([F:5])([F:4])[F:3].[FH:14]

Participants

6

Reactant 3

HCID 3763IsofluraneHCID 14917Hydrofluoric AcidHCID 42113Desflurane

Product 2

HCID 42113DesfluraneHCID 86625408Desflurane Hydrogen Fluoride

Reagents, catalysts & solvents 1

HCID 517277ChromiaCatalyst

Procedure

It has been found that fractional distillation of a crude reaction mixture obtained in the manufacture of desflurane, for example, by reacting hydrogen fluoride with isoflurane over a bed of chromia catalyst, results in the removal of desflurane in the form of a desflurane/hydrogen fluoride azeotrope that boils below the boiling point of hydrogen fluoride.

Workup

  1. distillationIt has been found that fractional distillation of a crude
  2. customreaction mixture

Sources & evidence

ORD record
ord-b089b2ff411140a2a8ecf40828639600
Source dataset
uspto-grants-2012_10
Patent number
US08283500B2

Linked notes

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