[CH2:1](SC1C=C(C=C[C:16]=1[C:17]([Cl:19])=O)C=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-:20].[Cl-].[Cl-].[Al+3].B(F)(F)F.[N+:28](C)([O-:30])=[O:29]>C(Cl)(Cl)(Cl)Cl.C(Cl)(Cl)Cl>[N+:28]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)([O-:30])=[O:29].[N+:28]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[CH3:1])([O-:30])=[O:29].[Cl-:19].[Cl:20][CH:17]([Cl:19])[CH3:16]The compound of formula (a), 3-benzylmercapto-4-chlorocarbonyl benzaldehyde, prepared according to the procedure set forth in the Preparation below, is cyclized with a Lewis acid, e.g., aluminum trichloride, stannic chloride, boron trifluoride, and the like, in the presence of an inert organic solvent, e.g., nitromethane, nitrobenzene, nitrotoluene, methylene, chloride, chloroform, carbon tetrachloride, dichloroethane, and the like, or mixtures thereof, at a temperature of from about 0° to about 40° C, for from about 5 minutes to about 3 hours, preferably from about 15° to about 20° C, for from about 10 minutes to about 2 hours, to obtain the novel non-pharmaceutical intermediate compound of formula (1), 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-carboxaldehyde.
Loading…
