Acetic Acid → HCID 57501273, compound

2.0 M methylamine solution in THF (55 mL, 110.0 mmol) was added to a solution of 1-(3-bromophenyl)-2-(1-pyrrolidinyl)ethanone (7.40 g, 27.62 mmol) in anhydrous THF (30 mL) at room temperature. The reaction mixture was stirred for 1 h and then sodium cyanoborohydride (5.21 g, 82.86 mmol) and acetic acid (3 mL) were added. The resulting reaction mixture was continually stirred at room temperature for 96 h until the starting material was consumed completely. Saturated K2CO3 solution (100 mL) was added and after stirring for 15 min, the solution was extracted with ethyl acetate (2×80 mL). The organic layers were combined, dried over Na2SO4, and concentrated. The resulting residue was isolated by column chromatography on silica gel (MeOH/EtOAc, 1:10) to yield the title compound as a yellow oil (3.75 g, 48%), MS (ES) m/e 283[M+H]+.

1. customThe resulting reaction mixture
2. stirringwas continually stirred at room temperature for 96 h until the starting material
3. customwas consumed completely
4. additionSaturated K2CO3 solution (100 mL) was added
5. stirringafter stirring for 15 min
6. extractionthe solution was extracted with ethyl acetate (2×80 mL)
7. dry with materialdried over Na2SO4
8. concentrationconcentrated
9. customThe resulting residue was isolated by column chromatography on silica gel (MeOH/EtOAc, 1:10)

ORD record

ord-89344b6e86c04c50874d110f700bb063

Source dataset

uspto-grants-2008_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07432258B2