Hydrochloric Acid → 5-Bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylic acid

Reaction equation

[Br:1][c:2]1[c:3](-[c:12]2[cH:13][c:14]([Cl:19])[c:15]([F:18])[cH:16][cH:17]2)[n:4][c:5]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[s:6]1.[ClH:23].[Li+:20].[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1.[OH-:21].[OH2:22]>>[Br:1][c:2]1[c:3](-[c:12]2[cH:13][c:14]([Cl:19])[c:15]([F:18])[cH:16][cH:17]2)[n:4][c:5]([C:7](=[O:8])[OH:9])[s:6]1

Participants

Reactant 6

HCID 313Hydrochloric Acid

HCID 961Hydroxide

HCID 962Water

HCID 8028Tetrahydrofuran

HCID 28486Lithium ion

HCID 70801639Ethyl 5-bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate

Product 1

HCID 708016435-Bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylic acid

Sources & evidence

ORD record: ord-4c694a2339164f589cdb78ae488e9238
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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