Ammonium → 5-Bromo-2-fluoro-4-(hydroxymethyl)benzaldehyde

HRID 213644

Reaction equation

HRID 213644 reaction equation
[Br:16][c:17]1[c:18]([CH2:24][OH:25])[cH:19][c:20]([F:23])[cH:21][cH:22]1.[CH2:11]([Li:12])[CH2:13][CH2:14][CH3:15].[CH3:1][CH:2]1[CH2:3][CH2:4][CH2:5][N:6]([CH3:7])[C:8]1([CH3:9])[CH3:10].[CH3:26][N:27]([CH:28]=[O:29])[CH3:30].[Cl-:31].[NH4+:32].[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1>>[Br:16][c:17]1[c:18]([CH2:24][OH:25])[cH:19][c:20]([F:23])[c:21]([CH:28]=[O:29])[cH:22]1

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 27733492-Bromo-5-fluorobenzyl alcoholHCID 187617721,2,2,3-TetramethylpiperidineHCID 178418339Butyllithium

Product 1

HCID 592789305-Bromo-2-fluoro-4-(hydroxymethyl)benzaldehyde

Sources & evidence

ORD record
ord-185b3b4859074f40977b448b0523a1ff
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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