Hydrochloric Acid → N-[5-({2-[(cyclopropylsulfonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

HRID 2154224

Reaction equation

HRID 2154224 reaction equation
[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[CH3:45][N:46]1[CH2:47][CH2:48][CH2:49][C:50]1=[O:51].[CH:37]1([S:40](=[O:41])(=[O:42])[Cl:43])[CH2:38][CH2:39]1.[ClH:1].[NH2:2][c:3]1[n:4][c:5]2[n:6]([n:7][c:8]([O:11][c:12]3[cH:13][cH:14][c:15]([F:28])[c:16]([NH:18][C:19](=[O:20])[c:21]4[cH:22][c:23]([CH3:27])[n:24][n:25]4[CH3:26])[cH:17]3)[cH:9][cH:10]2)[cH:29]1.[OH2:44]>>[NH:2]([c:3]1[n:4][c:5]2[n:6]([n:7][c:8]([O:11][c:12]3[cH:13][cH:14][c:15]([F:28])[c:16]([NH:18][C:19](=[O:20])[c:21]4[cH:22][c:23]([CH3:27])[n:24][n:25]4[CH3:26])[cH:17]3)[cH:9][cH:10]2)[cH:29]1)[S:40]([CH:37]1[CH2:38][CH2:39]1)(=[O:41])=[O:42]

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 962WaterHCID 8471TriethylamineHCID 13387N-methyl-2-pyrrolidoneHCID 2760919Cyclopropanesulfonyl chlorideHCID 57505568N-[5-(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy-2-fluorophenyl]-2,5-dimethylpyrazole-3-carboxamide

Product 1

HCID 57505601N-[5-({2-[(cyclopropylsulfonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

Sources & evidence

ORD record
ord-b99f20647c2a458097e75d223cde925d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Linked notes

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