Water → 2-Fluoro-6-(methylamino)benzonitrile
Reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6](F)[C:3]=1[C:4]#[N:5].[CH3:11][NH2:12].O>CN(C=O)C>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([NH:12][CH3:11])[C:3]=1[C:4]#[N:5]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
2,6-Difluorobenzonitrile, 2.78 g (20 mmol) and 5 ml (60 mmol) of 40% aqueous methylamine in 50 ml DMF is stirred at room temperature for 1 hr., poured into water and the product is collected, 2.4 g m.p. 130°-132° C.
Workup
- customthe product is collected
Sources & evidence
- ORD record
- ord-d54ade8330034c1ab3d36e8d8ce7f104
- Source dataset
- uspto-grants-1985_03
- Patent number
- US04504660
Reaction notes
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