Hydrochloric Acid → 2-nitro-5-piperazin-1-yl-benzoic Acid
Reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:10](Cl)=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-:3])=[O:2].[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.Cl>O>[N+:1]([C:4]1[CH:12]=[CH:11][C:10]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-:3])=[O:2]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To the suspension of 50 g 2-nitro-5-chlorobenzoic acid in 750 ml water, 86 g of piperazine is added and the reaction mixture is heated at reflux temperature for 20 hours. The mixture is then neutralized with conc. hydrochloric acid and the precipitated crystalline material is filtered off and dried to obtain 62 g title compound (MH+: 252)
Workup
- additionis added
- temperaturethe reaction mixture is heated
- temperatureat reflux temperature for 20 hours
- filtrationthe precipitated crystalline material is filtered off
- customdried
Sources & evidence
- ORD record
- ord-849456b97daf4633bb5ea947dff32749
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08338411B2
Reaction notes
Loading…