Sorbitol → Aluminum Citrate Sorbitol Hydroxide

HRID 2206889

Reaction equation

HRID 2206889 reaction equation
[OH:1]C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.O.O.O.O.O.O.[Cl-].[Al+3:20].[Cl-].[Cl-].O.[C:24]([OH:36])(=[O:35])[CH2:25][C:26]([CH2:31][C:32]([OH:34])=[O:33])([C:28]([OH:30])=[O:29])[OH:27].[OH-].[Na+].[OH-].[OH:40][CH2:41][C@@H:42]([C@H:44]([C@@H:46]([C@@H:48]([CH2:50][OH:51])[OH:49])[OH:47])[OH:45])[OH:43].C([O-])(=O)CC(CC(O)=O)(C(O)=O)O.[Mg+2]>O.C(O)C>[OH-:1].[OH:51][CH2:50][C@@H:48]([C@H:46]([C@@H:44]([C@@H:42]([CH2:41][OH:40])[OH:43])[OH:45])[OH:47])[OH:49].[C:24]([O-:36])(=[O:35])[CH2:25][C:26]([CH2:31][C:32]([O-:34])=[O:33])([C:28]([OH:30])=[O:29])[OH:27].[Al+3:20]

Participants

8

Reactant 5

HCID 5780SorbitolHCID 14798Sodium Hydroxide2×HCID 222302-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)HCID 9794789AlCl3.6H2OHCID 86664106Magnesium citrate sorbitol hydroxide

Product 1

HCID 86664105Aluminum Citrate Sorbitol Hydroxide

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

800 g of sorbitol, 600 g of aluminum chloride hexahydrate, and 250 g of citric acid monohydrate were dissolved in 3000 g of water at 70° C. with stirring to produce a solution. The pH of the solution was raised to about 8 by adding an aqueous solution containing 20 wt % of sodium hydroxide. After the addition of NaOH, a colorless and transparent nanocluster solution having a strong laser scattering characteristic was then obtained instantly. This strong laser scattering property indicated formation of magnesium citrate sorbitol hydroxide nanoclusters. The nanoclusters were further isolated by adding ethanol into the solution to precipitate the magnesium citrate sorbitol hydroxide nanoclusters. Or the nanoclusters were isolated from the solvent and free ions through a cross-flow membrane filtration device using a membrane with a molecular weight cut-off at 3500 Dalton. The isolated nanoclusters were further dried in an oven at 80° C. to form a solid.

Workup

  1. customto produce a solution
  2. temperatureThe pH of the solution was raised to about 8
  3. additionby adding an aqueous solution
  4. customwas then obtained instantly
  5. customThe nanoclusters were further isolated
  6. customto precipitate the magnesium citrate sorbitol hydroxide nanoclusters
  7. customOr the nanoclusters were isolated from the solvent and free ions through a cross-flow membrane filtration device
  8. customThe isolated nanoclusters were further dried in an oven at 80° C.
  9. customto form a solid

Sources & evidence

ORD record
ord-438f690f5ba140b59f01179b43b89713
Source dataset
uspto-grants-2016_06
Patent number
US09375449B2

Linked notes

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