Hydrochloric Acid → 2-Propenoic acid, 3-phenyl-

HRID 22091

Reaction equation

HRID 22091 reaction equation
O[C:2]1[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+].N#N.C1OC1CO.Cl>CS(C)=O.OCC(CO)O>[C:8]([OH:10])(=[O:9])[CH:7]=[CH:6][C:5]1[CH:4]=[CH:3][CH:2]=[CH:12][CH:11]=1

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 3224-Coumaric acidHCID 947NitrogenHCID 11164GlycidolHCID 14798Sodium Hydroxide

Product 1

HCID 87842-Propenoic acid, 3-phenyl-

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 753GlycerolSolvent

Procedure

8.719 g of p-hydroxy cinnamic acid was dissolved in 10 ml of DMSO, and 100 mg of sodium hydroxide was added. The mixture was stirred and heated to 90° C. under a flow of N2 gas. 19.7 g of glycidol was added gradually, heating and agitation was carried out for 2 hours, neutralized by adding hydrochloric acid and then the adduct of cinnamic acid and glycerin was obtained.

Workup

  1. temperatureheating

Sources & evidence

ORD record
ord-b76ea8f01bb84b6080b39c1bfb6ab1c0
Source dataset
uspto-grants-1995_06
Patent number
US05426210

Linked notes

Loading…