Hydrochloric Acid → 2-Propenoic acid, 3-phenyl-
Reaction equation
O[C:2]1[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[K+].N#N.C1OC1CO.Cl>CS(C)=O.OCC(CO)O>[C:8]([OH:10])(=[O:9])[CH:7]=[CH:6][C:5]1[CH:4]=[CH:3][CH:2]=[CH:12][CH:11]=1Participants
8
Reactant 5
Product 1
Reagents, catalysts & solvents 2
Procedure
4.35 g of p-hydroxy cinnamic acid was dissolved in 5 ml of DMSO, and 50 mg of potassium hydroxide was added. The mixture was stirred and heated to 90° C. under flow of N2 gas. 10.0 g of glycidol was added gradually, heating and agitation was carried out for 1.5 hours, neutralized by adding hydrochloric acid and the adduct of cinnamic acid and glycerin was obtained.
Workup
- temperatureheating
Sources & evidence
- ORD record
- ord-542a9da6771c4edf9109f3992e977503
- Source dataset
- uspto-grants-1995_06
- Patent number
- US05426210
Reaction notes
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