Reaction equation
[S:1]1CC(O)S[CH2:3][CH:2]1O.[C:9]([CH2:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])#[N:10].C(N(CC)CC)C.O>O1CCCC1.C(O)(=O)C>[C:15]([O:14][C:12]([C:11]1[CH:3]=[CH:2][S:1][C:9]=1[NH2:10])=[O:13])([CH3:18])([CH3:17])[CH3:16]Participants
Conditions
- Temperature
- 50 °C
Procedure
A solution of 1,4 dithiane-2,5-diol (1.1 g) and t-butyl cyanoacetate (2.2 ml) in dry tetrahydrofuran (20 ml) was warmed to ˜45° C. then treated slowly with triethylamine (2ml). The temperature rose to ˜54° C. and a yellow colouration developed. The mixture was stirred at ˜50° C. for a further 75 mins during which time the colour gradually darkened and became brownish. Water (200 ml) was added, then the mixture was acidified with acetic acid and extracted with ether. The ether extracts were washed with water, dried on magnesium sulfate, filtered and concentrated in vacuo. Residual acetic acid was removed by azeotropic distillation with toluene. The resulting brown liquid was identified as the desired product by NMR. The sample was used without further purification.
Workup
- customrose to ˜54° C.
- extractionextracted with ether
- washThe ether extracts were washed with water
- customdried on magnesium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
- customResidual acetic acid was removed by azeotropic distillation with toluene
- customThe sample was used without further purification
Sources & evidence
- ORD record
- ord-cadd76ea74b9472fb702dddd30b91233
- Source dataset
- uspto-grants-2008_08
- Patent number
- US07407954B2
Linked notes
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