4-Methyl-5-(2-hydroxyethyl)thiazole → 5-Thiazoleethanol, 4-methyl-, 5-methanesulfonate

HRID 227381

Reaction equation

HRID 227381 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH2:7][CH2:8][OH:9].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1COCC1>[CH3:17][S:18]([O:9][CH2:8][CH2:7][C:6]1[S:5][CH:4]=[N:3][C:2]=1[CH3:1])(=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 11364-Methyl-5-(2-hydroxyethyl)thiazoleHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

Product 1

HCID 101049265-Thiazoleethanol, 4-methyl-, 5-methanesulfonate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The 4-methyl-5-thiazole ethanol (Aldrich, 0.18 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Sources & evidence

ORD record
ord-e3ac47f2f60440cba9fad8d793c7a4e0
Source dataset
uspto-grants-2009_07
Patent number
US07560481B2

Linked notes

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