Triethylamine → Methanesulfonic acid 2-(1-methyl-pyrrolidin-2-yl)-ethyl ester

HRID 227384

Reaction equation

HRID 227384 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][OH:9].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1COCC1>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][O:9][S:18]([CH3:17])(=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 933631-Methyl-2-pyrrolidineethanol

Product 1

HCID 44627019Methanesulfonic acid 2-(1-methyl-pyrrolidin-2-yl)-ethyl ester

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The 1-methyl-2-pyrrolidineethanol (Aldrich, 0.16 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Sources & evidence

ORD record
ord-0dbdb683028e47d7a0c4b45b508af8c3
Source dataset
uspto-grants-2009_07
Patent number
US07560481B2

Linked notes

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