[Cl:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][N:17]=1)[C:5]([O:7]C1C=CC=C(C)C=1)=O.[C:18]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:19]([S:24]([NH2:27])(=[O:26])=[O:25])=[CH:20][CH:21]=[CH:22][CH:23]=1.C(=O)([O-])[O-].[K+].[K+].C(=O)=O.Cl>C(OCC)(=O)C.O>[C:18]1([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:19]([S:24]([NH:27][C:5](=[O:7])[C:4]2[CH:15]=[CH:16][N:17]=[C:2]([Cl:1])[CH:3]=2)(=[O:26])=[O:25])=[CH:20][CH:21]=[CH:22][CH:23]=12.4 g (0.01 mol ) of 3-methylphenyl 2-chloroisonicotinate, 2.3 g (0.01 mol) of 2-biphenylsulfonamide and 1.4 g (0.01 mol) of anhydrous potassium carbonate were melted under agitation at 120° to 130° C. When the generation of gaseous carbon dioxide came to an end after 30 min to 1 hr., 50 ml of water were added and, then concentrated hydrochloric acid dropwise added to acidify. The organic layer obtained by extraction with ethyl acetate was dried and then concentrated to precipitate crude crystals, which were recrystallized to 1.6 g (yield: 42.9%) of N-(2-biphenylsulfonyl)-2-chloroisonicotinamide as white crystals.
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