Potassium Cation → 3-[2-(3-Methyl-isoxazol-5-yl)-pyridin-4-yl]-3-oxo-propionic acid tert.-butyl ester

HRID 2322077Notes

Reaction equation

HRID 2322077 reaction equation
[C:52]([CH3:53])(=[O:54])[O:55][C:56]([CH3:57])([CH3:58])[CH3:59].[CH3:17][O:18][C:19](=[O:20])[c:21]1[cH:22][cH:23][n:24][c:25]([I:26])[cH:27]1.[CH3:1][O:2][C:3]([c:4]1[cH:5][c:6](-[c:10]2[cH:11][c:12]([CH3:15])[n:13][o:14]2)[n:7][cH:8][cH:9]1)=[O:16].[CH3:28][Si:29]([C:30]#[CH:31])([CH3:32])[CH3:33].[CH3:61][OH:62].[CH3:73][CH2:74][N:75]([CH2:76][CH3:77])[CH2:78][CH3:79].[CH:48](=[N:49][OH:50])[CH3:51].[Cl:40][N:41]1[C:42](=[O:43])[CH2:44][CH2:45][C:46]1=[O:47].[Cl:63][CH:64]([Cl:65])[Cl:66].[K+:34].[K+:35].[Li:60].[O-:36][C:37]([O-:38])=[O:39].[cH:67]1[cH:68][cH:69][n:70][cH:71][cH:72]1>>[C:3]([c:4]1[cH:5][c:6](-[c:10]2[cH:11][c:12]([CH3:15])[n:13][o:14]2)[n:7][cH:8][cH:9]1)(=[O:16])[CH2:53][C:52](=[O:54])[O:55][C:56]([CH3:57])([CH3:58])[CH3:59]

Participants

14

Reactant 13

HCID 813Potassium Cation2×HCID 887MethanolHCID 1049PyridineHCID 6212ChloroformHCID 7863AldoximeHCID 8471TriethylamineHCID 10908tert-Butyl acetateHCID 19660Carbonate IonHCID 31398ChlorosuccinimideHCID 66111TrimethylsilylacetyleneHCID 196869Methyl 2-iodoisonicotinateHCID 3028194LithiumHCID 696879722-(3-Methyl-isoxazol-5-yl)-isonicotinic acid methyl ester

Product 1

HCID 696881723-[2-(3-Methyl-isoxazol-5-yl)-pyridin-4-yl]-3-oxo-propionic acid tert.-butyl ester

Sources & evidence

ORD record
ord-d258dceb1ce94a9185436168719d65e2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…