Piperidine → 1-(4-Trimethylsilanylethynylbenzyl)pyrrolidine

Reaction equation

[CH2:14]1[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]1.[CH3:20][Si:21]([CH3:22])([CH3:23])[C:24]#[CH:25].[Cu:26][I:27].[I:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[CH2:8][CH2:9][CH2:10][CH2:11]2)[cH:12][cH:13]1>>[c:2]1([C:25]#[C:24][Si:21]([CH3:20])([CH3:22])[CH3:23])[cH:3][cH:4][c:5]([CH2:6][N:7]2[CH2:8][CH2:9][CH2:10][CH2:11]2)[cH:12][cH:13]1

Participants

Reactant 4

HCID 8082Piperidine

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 66111Trimethylsilylacetylene

HCID 185258671-(4-Iodobenzyl)pyrrolidine

Product 1

HCID 688167401-(4-Trimethylsilanylethynylbenzyl)pyrrolidine

Sources & evidence

ORD record: ord-e1e4e3bb1aad4ea88945f37ab712f4c8
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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