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2-Bromopyridine → 8-(2-Pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane

HRID 236
Notes
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Reaction equation

HRID 236 reaction equation
Brc1ccccn1.C1CC2(CCN1)OCCO2>CC(=O)O.CC(=O)O.CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.[Na+].[Pd]>c1ccc(N2CCC3(CC2)OCCO3)nc1
ParticipantsProcedureSources & evidenceReaction notes

Participants

6

Reactant 2

HCID 79732-BromopyridineHCID 674351,4-Dioxa-8-azaspiro(4.5)decane

Product 1

HCID 120337658-(2-Pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decaneYield 66.56%

Reagents, catalysts & solvents 3

HCID 23676156Sodium t-butoxideReagentHCID 4144353Palladium (II) acetateCatalystHCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylCatalyst

Procedure

The same procrdure as EN03653-93-01.

Sources & evidence

ORD record
ord-00b95f6f20354bb6923efd18c2b3c116
Source dataset
750 AstraZeneca ELN dataset
Original link
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Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes