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Triethylamine → 4-[1,2,4]Triazol-1-yl-benzoic acid 3-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-benzylamide

HRID 2367741
Notes
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Reaction equation

HRID 2367741 reaction equation
[N:1]1([C:6]2[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[CH:8][CH:7]=2)[CH:5]=[N:4][CH:3]=[N:2]1.Cl.Cl.[NH2:17][CH2:18][C:19]1[CH:20]=[C:21]([CH:36]=[CH:37][CH:38]=1)[C:22]([NH:24][C:25]1[CH:34]=[C:33]2[C:28]([CH2:29][CH2:30][N:31]([CH3:35])[CH2:32]2)=[CH:27][CH:26]=1)=[O:23].C(N(CC)CC)C>CN(C=O)C.O.FC(F)(F)C(O)=O>[CH3:35][N:31]1[CH2:30][CH2:29][C:28]2[C:33](=[CH:34][C:25]([NH:24][C:22]([C:21]3[CH:20]=[C:19]([CH:38]=[CH:37][CH:36]=3)[CH2:18][NH:17][C:10](=[O:12])[C:9]3[CH:8]=[CH:7][C:6]([N:1]4[CH:5]=[N:4][CH:3]=[N:2]4)=[CH:14][CH:13]=3)=[O:23])=[CH:26][CH:27]=2)[CH2:32]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 3

HCID 8471TriethylamineHCID 7365314-(1H-1,2,4-Triazol-1-yl)benzoic acidHCID 666490723-(2-Methyl-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)benzylamine dihydrochloride

Product 1

HCID 666561554-[1,2,4]Triazol-1-yl-benzoic acid 3-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-benzylamideYield 61.4%

Reagents, catalysts & solvents 3

HCID 962
Water
Solvent
HCID 6228DimethylformamideSolvent
HCID 6422Trifluoroacetic acidSolvent

Procedure

Dissolve 4-[1,2,4]triazol-1-yl-benzoic acid (29 mg, 0.15 mmol) and CDI (N,N′-carbonyldiimidazole) (25 mg, 0.15 mmol) in DMF (2 mL) and stir the mixture for 1 h. To this add 3-aminomethyl-N-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-benzamide dihydrochloride (50 mg, 0.14 mmol) and triethylamine (0.095 mL, 0.68 mmol) and stir the mixture overnight. Dilute the mixture with water (1 mL) and trifluoroacetic acid (0.2 mL) and purify by prep-HPLC (5%-70%, CH3CN/H2O) to give the desired product 4-[1,2,4]triazol-1-yl-benzoic acid 3-(2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-benzylamide (51 mg, 0.086 mmol). MS, electrospray 467.4 (M+H), rt 1.05 min.

Workup

  1. custompurify by prep-HPLC (5%-70%, CH3CN/H2O)

Sources & evidence

ORD record
ord-b55b6da6675d4c178bf3050d6b670a22
Source dataset
uspto-grants-2014_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08697911B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes