Sodium hydride → tert-butyl (2R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-[2-(6-cyano-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethyl]piperidine-1-carboxylate

Reaction equation

[Si:1]([O:8][C@H:9]1[CH2:14][N:13]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C@@H:12]([CH2:22][CH2:23]O)[CH2:11][CH2:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].C(N(C(C)C)CC)(C)C.CS(Cl)(=O)=O.[O:39]=[C:40]1[NH:45][C:44]2[CH:46]=[C:47]([C:50]#[N:51])[CH:48]=[CH:49][C:43]=2[O:42][CH2:41]1.[H-].[Na+].S([O-])(=O)(=O)C>C(Cl)Cl.CN(C=O)C>[Si:1]([O:8][C@H:9]1[CH2:14][N:13]([C:15]([O:17][C:18]([CH3:21])([CH3:19])[CH3:20])=[O:16])[C@@H:12]([CH2:22][CH2:23][N:45]2[C:44]3[CH:46]=[C:47]([C:50]#[N:51])[CH:48]=[CH:49][C:43]=3[O:42][CH2:41][C:40]2=[O:39])[CH2:11][CH2:10]1)([C:4]([CH3:6])([CH3:5])[CH3:7])([CH3:3])[CH3:2]