4-Iodoaniline → N-(4-iodophenyl)-N-methylethanesulphonamide

HRID 256607

Reaction equation

[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.I[C:10]1C=CC(NS(C)(=O)=O)=CC=1.[CH2:21]([S:23](Cl)(=[O:25])=[O:24])[CH3:22]>>[I:1][C:2]1[CH:8]=[CH:7][C:5]([N:6]([CH3:10])[S:23]([CH2:21][CH3:22])(=[O:25])=[O:24])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 108934-Iodoaniline

HCID 11667Ethanesulfonyl chloride

HCID 836147N-(4-iodophenyl)methanesulfonamide

Product 1

HCID 19785600N-(4-iodophenyl)-N-methylethanesulphonamide

Procedure

The product so obtained was used in place of 4-iodoaniline in the procedure described in Example 3 for the preparation of N-(4-iodophenyl) methanesulphonamide and ethanesulphonyl chloride was used in place of methanesulphonyl chloride. Thus was obtained N-(4-iodophenyl)-N-methylethanesulphonamide as an oil. NMR Spectrum 1.45 (3H, t), 3.00 (2H, q), 3.35 (3H, s), 7.15 (2H, m), 7.70 (2H, m).

Workup

customThe product so obtained

Sources & evidence

ORD record: ord-5611fef512954a2ea8368584f719a99e
Source dataset: uspto-grants-1993_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05258399

Linked notes

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