Acetic Acid → Propionic Acid

HRID 260999

Reaction equation

HRID 260999 reaction equation
[P].C(P(=O)([CH2:7][CH3:8])CC)C.C1(P(=O)([C:23]2[CH:28]=[CH:27]C=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(P(=O)(CCCC)CCCC)CCC.P(OCC)(OCC)O[CH2:46]C.P(OCCCC)(OCCCC)OCCCC.P(OC1C=CC=CC=1)(OC1C=CC=CC=1)OC1C=CC=CC=1.[C:92]([OH:95])(=[O:94])C>O>[C:92]([OH:95])(=[O:94])[CH2:7][CH3:8].[C:92]([OH:95])(=[O:94])[C:28]([CH3:27])([CH3:23])[CH3:46]

Participants

11

Reactant 8

HCID 176Acetic AcidHCID 7540Triphenyl phosphiteHCID 7623Tributyl phosphiteHCID 13097Triphenylphosphine OxideHCID 13138Tributylphosphine oxideHCID 31215Triethyl phosphiteHCID 79061Triethylphosphine oxideHCID 5462309Phosphorus

Product 2

HCID 1032Propionic AcidHCID 6417Pivalic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

For the purpose of improving catalytic activity, regio and enantio selectivities, various additives other than water may be added to the reaction system. For example, presence of phosphorus compounds, e.g., triethylphosphine oxide, triphenylphosphine oxide, tributylphosphine oxide, triethyl phosphite, tributyl phosphite, and triphenyl phosphite; or carboxylic acids, e.g., acetic acid, propionic acid and pivalic acid, in the reaction system gives rise to no interference with the reaction.

Workup

  1. additionmay be added to the reaction system

Sources & evidence

ORD record
ord-031fc845957442cea12fa81f62ac114d
Source dataset
uspto-grants-1996_06
Patent number
US05530150

Linked notes

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