p-Toluenesulfonic acid → 1-Ethoxy-1-(imidazol-4-yl)methoxy ethane

HRID 279847

Reaction equation

HRID 279847 reaction equation
Cl.[OH:2][CH2:3][C:4]1[N:5]=[CH:6][NH:7][CH:8]=1.[CH:9]([O:11][CH2:12][CH3:13])=[CH2:10].C1(C)C=CC(S(O)(=O)=O)=CC=1>CN(C)C=O>[CH2:9]([O:11][CH:12]([O:2][CH2:3][C:4]1[N:5]=[CH:6][NH:7][CH:8]=1)[CH3:13])[CH3:10]

Participants

5

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 8023Ethyl vinyl etherHCID 178418488HCID 178418488, compound

Product 1

HCID 1784680041-Ethoxy-1-(imidazol-4-yl)methoxy ethane

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a flask containing 4 gms 4-hydroxymethyl imidazole hydrochloride in 30 ml dimethylformamide add 3.1 ml vinylethyl ether and 50 mg paratoluene sulfonic acid. Stir for 11/2 hours until the reaction is complete. Extract from saturated K2CO3 /NaCl with ethylacetate to obtain 1-ethoxy-1-(imidazol-4-yl)methoxy ethane.

Workup

  1. extractionExtract from saturated K2CO3 /NaCl with ethylacetate

Sources & evidence

ORD record
ord-66bf058a84f94f76b34dcf0fdc9167ee
Source dataset
uspto-grants-1986_05
Patent number
US04587241

Linked notes

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