Tetrahydrofuran → 3-bromo-4-[4-[2-methyl-5-[2-(2-pyrrolidin-1-ylethoxy)phenyl]phenyl]piperazin-1-yl]-2H-pyrazolo[3,4-d]pyrimidine

HRID 283843

Reaction equation

HRID 283843 reaction equation
[Br:40][c:41]1[n:42][nH:43][c:44]2[n:45][cH:46][n:47][c:48]([Cl:50])[c:49]12.[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:1][c:2]1[c:3]([N:22]2[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]2)[cH:4][c:5](-[c:8]2[c:9]([O:14][CH2:15][CH2:16][N:17]3[CH2:18][CH2:19][CH2:20][CH2:21]3)[cH:10][cH:11][cH:12][cH:13]2)[cH:6][cH:7]1.[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[CH3:51][CH2:52][O:53][C:54]([CH3:55])=[O:56]>>[CH3:1][c:2]1[c:3]([N:22]2[CH2:23][CH2:24][N:25]([c:48]3[n:47][cH:46][n:45][c:44]4[nH:43][n:42][c:41]([Br:40])[c:49]43)[CH2:26][CH2:27]2)[cH:4][c:5](-[c:8]2[c:9]([O:14][CH2:15][CH2:16][N:17]3[CH2:18][CH2:19][CH2:20][CH2:21]3)[cH:10][cH:11][cH:12][cH:13]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 692459201-[2-Methyl-5-[2-(2-pyrrolidin-1-ylethoxy)phenyl]phenyl]piperazineHCID 1784783943-Bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine

Product 1

HCID 1784237223-bromo-4-[4-[2-methyl-5-[2-(2-pyrrolidin-1-ylethoxy)phenyl]phenyl]piperazin-1-yl]-2H-pyrazolo[3,4-d]pyrimidine

Sources & evidence

ORD record
ord-b4777534815b40789a7bc88efb9d8bb3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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