Dimethylformamide → 6-(2-Methoxycarbonylamino-3-methyl-butyryl)-5-oxa-6-aza-spiro[3.4]octane-7-carboxylic acid ethyl ester

HRID 313183Notes

Reaction equation

HRID 313183 reaction equation
[CH2:37]([CH3:38])[O:39][C:40](=[O:41])[CH:42]1[NH:43][O:44][C:45]2([CH2:46][CH2:47][CH2:48]2)[CH2:49]1.[CH3:1][O:2][C:3](=[O:4])[NH:5][CH:6]([C:7](=[O:8])[OH:9])[CH:10]([CH3:11])[CH3:12].[CH3:59][N:60]([CH3:61])[CH:62]=[O:63].[CH3:64][CH2:65][O:66][C:67](=[O:68])[CH3:69].[CH:50]([N:51]([CH:52]([CH3:53])[CH3:54])[CH2:55][CH3:56])([CH3:57])[CH3:58].[P-:13]([F:14])([F:15])([F:16])([F:17])([F:18])[F:19].[n:20]1([O:21][C:22]([N:23]([CH3:24])[CH3:25])=[N+:26]([CH3:27])[CH3:28])[c:29]2[n:30][cH:31][cH:32][cH:33][c:34]2[n:35][n:36]1>>[CH3:1][O:2][C:3](=[O:4])[NH:5][CH:6]([C:7](=[O:9])[N:43]1[CH:42]([C:40]([O:39][CH2:37][CH3:38])=[O:41])[CH2:49][C:45]2([O:44]1)[CH2:46][CH2:47][CH2:48]2)[CH:10]([CH3:11])[CH3:12]

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 138211012-((Methoxycarbonyl)amino)-3-methylbutanoic acidHCID 59611538Ethyl 5-oxa-6-azaspiro[3.4]octane-7-carboxylate

Product 1

HCID 666206496-(2-Methoxycarbonylamino-3-methyl-butyryl)-5-oxa-6-aza-spiro[3.4]octane-7-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-d5848f81d68a47978895ab325a4fbfca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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