Reaction equation
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Na+].Cl[CH2:13][C:14](=[O:28])[CH2:15][C:16]([O:18][CH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:17].Cl>C1COCC1>[N:1]1([CH2:7][CH2:8][O:9][CH2:13][C:14](=[O:28])[CH2:15][C:16]([O:18][CH2:19][CH2:20][CH2:21][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[O:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Participants
Procedure
2-(1-Piperidinyl)ethanol (15 mL, 113 mmol) in THF (50 mL) was added dropwise to a suspension of sodium hydride (7 g, 175 mmol) in THF (200 mL) at 0° C. The mixture was then stirred for 1 h at room temperature, cooled to 0° C., 3-phenylpropyl 4-chloroacetoacetate (22 mL, 103 mmol) in THF (50 mL) was added dropwise and the reaction mixture was then stirred for 18 h whilst warming to room temperature. 1N Hydrochloric acid was added until the mixture was acidic and the aqueous layer was then separated. The organic layer was extracted twice more with 1N hydrochloric acid. The combined acid layers were made basic to pH 8 with sodium hydrogen carbonate and extracted with chloroform. The combined extracts were washed with brine, dried and evaporated to give the title compound (24 g) as an oil. Electrospray MS m/z 348 [M+H]+.
Workup
- temperaturecooled to 0° C.
- stirringthe reaction mixture was then stirred for 18 h
- temperaturewhilst warming to room temperature
- customthe aqueous layer was then separated
- extractionThe organic layer was extracted twice more with 1N hydrochloric acid
- extractionextracted with chloroform
- washThe combined extracts were washed with brine
- customdried
- customevaporated
Sources & evidence
- ORD record
- ord-a9f7ca5fb7cf4d46a7a423dcaa90353b
- Source dataset
- uspto-grants-2001_04
- Patent number
- US06218538B1
Linked notes
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