Triethylamine → Methyl 1-((acetylthio)methyl)cyclopropaneacetate

HRID 326942

Reaction equation

HRID 326942 reaction equation
OC[C:3]1([CH2:6][C:7]([O:9][CH3:10])=[O:8])[CH2:5][CH2:4]1.C(N([CH2:16][CH3:17])CC)C.[CH3:18][S:19](Cl)(=O)=O.C([O-])(O)=[O:24].[Na+].S([O-])(=O)(=O)C>ClCCl.CN(C=O)C>[C:16]([S:19][CH2:18][C:3]1([CH2:6][C:7]([O:9][CH3:10])=[O:8])[CH2:4][CH2:5]1)(=[O:24])[CH3:17]

Participants

8

Reactant 5

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 85257MethanesulfonateHCID 516892Sodium Bicarbonate2×HCID 29941748(1-Hydroxymethylcyclopropyl)acetic acid methyl ester

Product 1

HCID 53482060Methyl 1-((acetylthio)methyl)cyclopropaneacetate

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
-10 °C

Procedure

To a solution of the alcohol of Step 4 (28.2 g, 0.20 mol) and triethylamine (82 mL, 0.59 mol) in dichloromethane (1 L) cooled to -40° C. was added methanesulfonyl chloride (43.5 mL, 0.3 mol). The reaction mixture was warmed to -10° C. for 20 min and then an aqueous solution of NaHCO3 was added. The product was extracted with CH2Cl2, washed with brine and dried over Na2SO4. A portion of this mesylate (0.053 mol) was then dissolved in DMF (180 mL) and cooled to 0° C. Freshly prepared cesium thiol acetate (J. Org. Chem., 51, 3664, (1986)) (22 g, 0.11 mol) was added and the mixture was stirred overnight at r.t. The reaction mixture was poured into an aqueous solution of NaHCO3 and extracted with Et2O. The organic phases were washed with brine and dried over Na2SO4. The residual oil was then purified by flash chromatography with 10:1 hexane:EtOAc to yield 7.5 g, 70%, of the title compound.

Workup

  1. extractionThe product was extracted with CH2Cl2
  2. washwashed with brine
  3. dry with materialdried over Na2SO4
  4. temperaturecooled to 0° C
  5. extractionextracted with Et2O
  6. washThe organic phases were washed with brine
  7. dry with materialdried over Na2SO4
  8. customThe residual oil was then purified by flash chromatography with 10:1 hexane
  9. customEtOAc to yield 7.5 g, 70%

Sources & evidence

ORD record
ord-c7a5d75aec7f44b6a51c59dab759c847
Source dataset
uspto-grants-1993_12
Patent number
US05270324

Linked notes

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