[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[C:12]([C:13]([O:15][CH:16]([CH3:18])[CH3:17])=[O:14])=[C:11]([CH3:19])[NH:10][C:9]2[CH2:20][O:21][C:22](=[O:23])[C:8]1=2.[H-].[Na+].[CH2:26](I)[CH3:27]>CN(C)C=O>[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[C:12]([C:13]([O:15][CH:16]([CH3:17])[CH3:18])=[O:14])=[C:11]([CH3:19])[N:10]([CH2:26][CH3:27])[C:9]2[CH2:20][O:21][C:22](=[O:23])[C:8]1=210 mmol of isopropyl 4-(3-chloro-2-thienyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3.4-b]pyridine-3-carboxylate are dissolved in 25 ml of dimethylformamide and deprotonated with NaH, and 20 mmol of ethyl iodide are added. After the mixture has been stirred at room temperature for 1 hour, it is concentrated, water is added to the residue and the product is filtered off with suction and recrystallized from methanol.
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