[OH-].[Ca+2:2].[OH-].[N+]([O-])([O-])=O.[Ca+2].[N+]([O-])([O-])=O.[P:13](=[O:17])([OH:16])([OH:15])[OH:14].[P:18]([O-:22])([O-:21])([O-:20])=[O:19].[NH4+].[NH4+].[NH4+]>[OH-].[NH4+]>[P:13]([O-:17])([O-:16])([O-:15])=[O:14].[Ca+2:2].[P:18]([O-:22])([O-:21])([O-:20])=[O:19].[Ca+2:2].[Ca+2:2]The present invention also provides methods of synthesizing hydroxyapatite granules having homogenous cellular structures. A slurry of hydroxyapatite is prepared by dissolving calcium hydroxide or calcium nitrate in a saturated ammonium hydroxide solution. The ammonium hydroxide solution is pH 11 or greater. Phosphoric acid or ammonium phosphate is then added to this solution, preferably in a dropwise manner to produce a calcium-phosphate ratio of approximately 1.5 to 1.7.
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