Acetic Acid → Diethyl 2-butenedioate
Reaction equation
[C:1]([O:9][CH2:10][CH3:11])(=[O:8])[CH2:2][C:3](OCC)=O.C=O.[C:14]([O-:17])(=[O:16])C.[K+].[C:19](O)(=O)[CH3:20]>O.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[CH2:19]([O:17][C:14]([CH:3]=[CH:2][C:1]([O:9][CH2:10][CH3:11])=[O:8])=[O:16])[CH3:20]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 80 g of diethyl malonate, 30 g of paraformaldehyde, 5 g of potassium acetate, 5 g of copper (II) acetate monohydrate and 200 ml of acetic acid was heated at 90° to 100° C. for 2 hours. Acetic acid was removed from the reaction mixture under reduced pressure, and the residue was evaporated under reduced pressure to obtain 44 g of bis(ethoxycarbonyl)ethylene.
Workup
- temperaturewas heated at 90° to 100° C. for 2 hours
- customAcetic acid was removed from the reaction mixture under reduced pressure
- customthe residue was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-0ab178be1a0b47a9a0e79cc28e5ff348
- Source dataset
- uspto-grants-1995_05
- Patent number
- US05414081
Reaction notes
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