Hydrochloric Acid → Hydrochloric Acid

HRID 371724

Reaction equation

HRID 371724 reaction equation
[NH2:1][CH2:2][C:3]1([CH2:9][C:10]([OH:12])=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[ClH:13].[CH2:14](O)[CH3:15]>>[NH2:1][CH2:2][C:3]1([CH2:9][C:10]([O:12][CH2:14][CH3:15])=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[ClH:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 3446Gabapentin

Product 2

HCID 313Hydrochloric AcidHCID 15512485Ethyl 2-[1-(aminomethyl)cyclohexyl]acetate

Procedure

10 g. of the 1-aminomethyl-1-cyclohexane-acetic acid, prepared according to Example 1, are dissolved in 50 ml. anhydrous ethanol and saturated at 0° C. with gaseous hydrogen chloride. The reaction mixture is left to stand overnight at ambient temperature, then evaporated in a vacuum and the residue recrystallised from ethanol/ether. Ethyl 1-aminomethyl-1-cyclohexane-acetate is obtained in the form of its hydrochloride; m.p. 161° - 163° C.

Workup

  1. dissolutionare dissolved in 50 ml
  2. customsaturated at 0° C.
  3. waitThe reaction mixture is left
  4. customevaporated in a vacuum
  5. customthe residue recrystallised from ethanol/ether

Sources & evidence

ORD record
ord-405a81cc00a14ab4b6003f57296c8be8
Source dataset
uspto-grants-1978_05
Patent number
US04087544

Linked notes

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