Piperidine → Phe-Gly

HRID 39263

Reaction equation

HRID 39263 reaction equation
C1C2C(COC([NH:18][C@H:19]([C:27]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28])[CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=O)C3C(=CC=CC=3)C=2C=CC=1.N1CCCCC1>CN(C=O)C>[NH2:18][C@H:19]([C:27]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 11328236Fmoc-Phe-Gly-OH

Product 1

HCID 6992304Phe-Gly

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Fmoc-protected dipeptide 72 (500 mg, 1.00 mmol) was treated with a 5% v/v solution of piperidine in DMF (5 mL). After stirring for 1 h, the reaction mixture was concentrated to dryness. The crude material was used for the next step without purification.

Workup

  1. concentrationthe reaction mixture was concentrated to dryness
  2. customThe crude material was used for the next step without purification

Sources & evidence

ORD record
ord-f2ae1b8090a940d2913985de4b8df854
Source dataset
uspto-grants-2013_09
Patent number
US08524691B2

Linked notes

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