Piperidine → Glycyl-phenylalanyl-glycine

HRID 39265

Reaction equation

HRID 39265 reaction equation
C1C2C(COC([NH:18][CH2:19][C:20]([NH:22][C@H:23]([C:31]([NH:33][CH2:34][C:35]([OH:37])=[O:36])=[O:32])[CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:21])=O)C3C(=CC=CC=3)C=2C=CC=1.N1CCCCC1>CN(C=O)C>[NH2:18][CH2:19][C:20]([NH:22][C@H:23]([C:31]([NH:33][CH2:34][C:35]([OH:37])=[O:36])=[O:32])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:21]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 15222489N-Fmoc-glycyl-L-phenylalanyl-glycine

Product 1

HCID 6992441Glycyl-phenylalanyl-glycine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Fmoc-protected tripeptide 74 (546 mg, 0.98 mmol) was treated with a 5% v/v solution of piperidine in DMF (5 mL). After stirring for 45 min, the reaction mixture was concentrated to dryness. The crude material was used for the next step without purification.

Workup

  1. concentrationthe reaction mixture was concentrated to dryness
  2. customThe crude material was used for the next step without purification

Sources & evidence

ORD record
ord-7e66b13904154ebcbe524b75757fe2f1
Source dataset
uspto-grants-2013_09
Patent number
US08524691B2

Linked notes

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