Hydrochloric Acid → HCID 57897247, compound

Temperature

45 °C

To a mixture of 5-bromo-4-chloro-3-nitro-pyridin-2-ylamine (0.126 g, 0.50 mmol) and isopropanol (9 ml) was added 2-phenoxy-1-(piperazin-1-yl)ethanone×HCl (0.141 g, 0.55 mmol) followed by diisopropylethylamine (0.20 ml, 1.10 mmol). The reaction mixture was heated at 45° C. for 22 h, then allowed to cool to room temperature and diluted with isopropanol (4 ml). The precipitate was collected by filtration and washed with isopropanol and diethyl ether. The title compound was thus obtained as a yellow solid (0.163 g, 75%). 1H-NMR (500 MHz, DMSO-d6) 3.08 (br s) and 3.59 (br s) (8H, 2× piperazine N(CH2)2), 4.87 (s, 2H, COCH2O), 6.93 (m, 3H) and 7.28 (m, 2H) (ArH), 7.08 (s, 2H, NH2), 8.21 (s, 1H, 6-H);

1. temperatureto cool to room temperature
2. filtrationThe precipitate was collected by filtration
3. washwashed with isopropanol and diethyl ether

ORD record

ord-28f39c5bc5544e3a807c47b236eda291

Source dataset

uspto-grants-2012_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08088761B2