1,2-Dichloroethane → N1-(4-(2-(3-(tert-Butyldimethylsilyloxy)azetidine-1-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-methoxyphenyl)malonamide

Reaction equation

[NH2:1][C:2]1[CH:31]=[CH:30][C:5]([O:6][C:7]2[CH:12]=[CH:11][N:10]=[C:9]3[CH:13]=[C:14]([C:16]([N:18]4[CH2:21][CH:20]([O:22][Si:23]([C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:25])[CH3:24])[CH2:19]4)=[O:17])[S:15][C:8]=23)=[C:4]([F:32])[CH:3]=1.[CH3:33][O:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[NH:41][C:42](=[O:47])[CH2:43][C:44](O)=[O:45].C(Cl)CCl>CN(C=O)C.CCOC(C)=O>[Si:23]([O:22][CH:20]1[CH2:21][N:18]([C:16]([C:14]2[S:15][C:8]3[C:9](=[N:10][CH:11]=[CH:12][C:7]=3[O:6][C:5]3[CH:30]=[CH:31][C:2]([NH:1][C:44](=[O:45])[CH2:43][C:42]([NH:41][C:36]4[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=4[O:34][CH3:33])=[O:47])=[CH:3][C:4]=3[F:32])[CH:13]=2)=[O:17])[CH2:19]1)([C:26]([CH3:27])([CH3:28])[CH3:29])([CH3:25])[CH3:24]