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Furfural → (2,6-Dimethyl-phenyl)-(5-furan-2-yl-imidazo[1,2-b][1,2,4]triazol-6-yl)-amine

HRID 431200
Notes
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Reaction equation

HRID 431200 reaction equation
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.[CH3:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[C:9]=1[N+:15]#[C-:16].[CH:17](=O)[C:18]1[O:22][CH:21]=[CH:20][CH:19]=1>Cl(O)(=O)(=O)=O>[CH3:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[C:9]=1[NH:15][C:16]1[N:3]2[NH:4][CH:5]=[N:6][C:2]2=[N:1][C:17]=1[C:18]1[O:22][CH:21]=[CH:20][CH:19]=1
ParticipantsProcedureSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 7362FurfuralHCID 760092,6-Dimethylphenyl isocyanideHCID 178418311HCID 178418311, compound

Product 1

HCID 22335545(2,6-Dimethyl-phenyl)-(5-furan-2-yl-imidazo[1,2-b][1,2,4]triazol-6-yl)-amine

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound 18 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 3-amino-1,2,4-triazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) 2,6-dimethylphenylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) furfural solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) in a substance library.

Sources & evidence

ORD record
ord-2040e4a754bb4780b7d21539a72081b8
Source dataset
uspto-grants-2003_12
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06657064B2

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes