Trifluoroacetic acid → L-Lysine

HRID 446697

Reaction equation

CC(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([NH2:17])[C:14]([OH:16])=[O:15])=O)(C)C.C(O)(C(F)(F)F)=O>>[NH2:17][C@H:13]([C:14]([OH:16])=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9][NH2:8]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 2733283(2S)-2-amino-6-(((tert-butoxy)carbonyl)amino)hexanoic acid

Product 1

HCID 5962L-Lysine

Procedure

A portion of 40.0 mg (18.9 μmol, 1.00 eq) of PMB-protected (Trimer-lys(Boc))2-TEGDA OMe was treated with hot TFA according to general procedure E to yield (Trimer-Lys)2-TEGDA as a colorless solid. Yield: 26.0 mg (18.3 μmol, 97%).

Sources & evidence

ORD record: ord-46f7845c85f246f49a355a5e54230598
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08481494B2

Linked notes

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