Cyclohexanone, 2-hydroxy- → 3-Methyl-4,6,7,8-tetrahydro-2(3H)-naphthalenone

HRID 478073

Reaction equation

HRID 478073 reaction equation
O[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=O.CC1C(=O)CCCC=1C.[CH3:18][CH2:19][C:20](=[O:23])[CH:21]=[CH2:22].[OH-].[K+].[Li+].CC([N-]C(C)C)C>CO.C1COCC1>[CH3:22][CH:21]1[CH2:6][C:7]2[C:18]([CH2:5][CH2:4][CH2:3][CH:2]=2)=[CH:19][C:20]1=[O:23]

Participants

8

Reactant 5

HCID 10785Cyclohexanone, 2-hydroxy-HCID 14797Potassium HydroxideHCID 153941-Penten-3-oneHCID 2724682Lithium diisopropylamideHCID 108878982,3-Dimethyl-2-cyclohexen-1-one

Product 1

HCID 109098813-Methyl-4,6,7,8-tetrahydro-2(3H)-naphthalenone

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

This material is prepared according to the procedure for Preparation 5 wherein 2-hydroxycyclohexanone is substituted for 2,3-dimethylcyclohexenone, methylbutenone is substituted for MVK, and 2N KOH in MeOH is substituted fro LDA in THF.

Workup

  1. customThis material is prepared

Sources & evidence

ORD record
ord-ace3d167981649f5b92a1c86044c0fb5
Source dataset
uspto-grants-1989_12
Patent number
US04889947

Linked notes

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